Triethylamine (molecular formula: C6H15N), also known as N,N-diethylethylamine, is the simplest homotrisubstituted tertiary amine. It has the typical properties of tertiary amines, including salt formation and oxidation. Triethylamine has no reaction in the Hisberg reaction. It is a colorless to light yellow transparent liquid with a strong ammonia odor and a slight smoke in the air. Boiling point: 89.5℃, relative density (water = 1): 0.70, relative density (air = 1): 3.48, slightly soluble in water, soluble in ethanol and ether. The aqueous solution is alkaline. It is flammable, and its vapor can form an explosive mixture with air, with an explosion limit of 1.2% to 8.0%. It is toxic and highly irritating.

Triethylamine Chemical Properties

Safety Information

Product Application of Triethylamine CAS#121-44-8

1. Triethylamine can be used as a solvent and raw material in the organic synthesis industry. It can be used to prepare catalysts for phosgene-based polycarbonate, inhibitors for tetrafluoroethylene, rubber vulcanization accelerators, special solvents in paint strippers, enamel anti-hardening agents, surfactants, preservatives, bactericides, ion exchange resins, dyes, fragrances, drugs, high-energy fuels and liquid rocket propellants, etc. Products that consume triethylamine in the pharmaceutical industry include (consumption quota, t/t): ampicillin sodium (0.465), amoxicillin (0.391), Pioneer IV (2.550), cefazolin sodium (2.442), cefradine (1.093), piperacillin (0.584), ketoconazole (8.00), vitamin B6 (0.502), fluoxic acid (Chemicalbook 10.00), praziquantel (0.667), thiotepa (1.970), penicillamine (1.290), berberine hydrochloride (0.030), isoprenaline (0.540), alprazolam (3.950), o-chlorophenylacetic acid (0.010) and pipemidic acid, etc.

2. Used in the preparation of quaternary amine compounds and the synthesis of catalysts, and also used as rubber vulcanization accelerators, penetrants and waterproofing agents;

3. Manufacture of quaternary ammonium compounds, synthesis of catalysts, rubber vulcanization accelerators, and photographers. Mobile phase modifier, used for separation of acidic, alkaline and neutral drugs by reverse phase high performance liquid chromatography (RP-HPLC).

4. Improve the separation of amino acids and amino acid amides by suppressing tailing. Used in the manufacture of medicines, pesticides, inhibitors, high energy fuels, rubber vulcanizers, etc.