4-Dimethylaminopyridine CAS#1122-58-3

4-Dimethylaminopyridine CAS#1122-58-3

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Chemical Name:4-Dimethylaminopyridine
CAS No.:1122-58-3
Molecular Formula:C7H10N2
Molecular weight:122.17
Sample: Available
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Product Description

Products Description of 4-Dimethylaminopyridine CAS#1122-58-3

4-dimethylaminopyridine, commonly referred to as DMAP, is a strong nucleophilic acylation catalyst. The resonance of the electron-donating dimethylamino group with the parent ring (pyridine ring) can strongly activate the nitrogen atoms on the ring for nucleophilic substitution, and significantly catalyze the acylation/esterification of alcohols and amines/acids with high resistance and low reactivity, with the activity of about 104~106 times that of pyridine. Acyl transfer is a common transformation in nature and organic synthesis, in which chiral DMAP is a common asymmetric acyl transfer catalyst.


4-Dimethylaminopyridine Chemical Properties

Melting point

112 °C

Boiling point

162 °C

density

0.906 g/mL at 25 °C

vapor pressure

0.169 hPa at 20 °C

refractive index

n20/D 1.431

Fp

110 °C

storage temp.

Store below +30°C.

solubility

methanol: 50 mg/mL, clear

form

prilled

pka

pKa (20°): 9.7

color

off-white to yellow

Odor

characteristic odor

PH Range

9.7 (10% aq soln)

PH

11 (60g/l, H2O, 20℃)

Water Solubility

76 g/L (25 ºC)

Merck

14,3389

BRN

110354

Stability:

Stable. Incompatible with acids, oxidizing agents.

LogP

1.34 at 25℃

CAS DataBase Reference

1122-58-3(CAS DataBase Reference)

NIST Chemistry Reference

4-Pyridinamine, N,N-dimethyl-(1122-58-3)

EPA Substance Registry System

4-(Dimethylamino)pyridine (1122-58-3)

Safety Information


Hazard Codes

T,C,T+,Xn,F

Risk Statements

25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19

Safety Statements

36/37/39-45-28A-26-28-36/37-53-27-22-16

RIDADR

UN 2811 6.1/PG 2

WGK Germany

3

RTECS

US8400000

Autoignition Temperature

420 °C

Hazard Note

Toxic/Corrosive

TSCA

T

HazardClass

8

PackingGroup

II

HS Code

29333999

Toxicity

LD50 orally in Rabbit: 140 mg/kg LD50 dermal Rabbit 90 mg/kg


Product Application of 4-Dimethylaminopyridine CAS#1122-58-3

Used for softening water, preparing high-purity water, refining radioactive elements, extracting iodine from seaweed, refining antibiotics, industrial wastewater treatment, etc.




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