4,4'-Diaminodiphenylsulfone CAS#80-08-0

4,4'-Diaminodiphenylsulfone CAS#80-08-0

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Highly Effective Anti-Leprosy Activity – Dapsone shows strong antibacterial effects against Mycobacterium leprae and is considered the first-line drug for leprosy treatment by inhibiting bacterial folic acid and protein synthesis.

Powerful Anti-Inflammatory and Antioxidant Action – It scavenges toxic oxygen free radicals, suppresses neutrophil activation, and reduces the release of inflammatory mediators, helping to protect tissues from inflammatory damage.

Extremely High Therapeutic Concentration – Oral administration of 100 mg achieves blood levels 500–600 times higher than the minimum inhibitory concentration required to suppress Mycobacterium leprae, ensuring strong and reliable antibacterial efficacy.

Broad Clinical Application Range – In addition to leprosy, dapsone is widely used in treating infectious diseases, inflammatory skin disorders, autoimmune bullous diseases, and urticaria, demonstrating versatile therapeutic potential.
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Product Description

Melting point175-177 °C(lit.)
Boiling point511.7±35.0 °C(Predicted)
Density1.2701 (rough estimate)
Vapor pressure0.004Pa at 25℃
Refractive index1.5950 (estimate)
Storage temp2-8°C
Solubility0.38g/l
FormCrystalline Powder
PkapKb 13.0(at 25℃)
ColorWhite to beige
PH5.5-7.5 (H2O, 20℃)(saturated aqueous solution)
Water Solubility<0.1 g/100 mL at 20 ºC
Merck142,822
BRN788055
BCS Class4,2
StabilityStable. Combustible. Incompatible with strong oxidizing agents.
InChIKeyMQJKPEGWNLWLTK-UHFFFAOYSA-N
LogP0.97 at 25℃
CAS DataBase Reference80-08-0(CAS DataBase Reference)
NIST Chemistry ReferenceDapsone(80-08-0)
IARC3 (Vol. 24, Sup 7) 1987
EPA Substance Registry SystemDapsone (80-08-0)

Safety Information

Hazard CodesXn
Risk Statements22
Safety Statements22
RIDADR3249
WGK Germany1
RTECSBY8925000
TSCAYes
HazardClass6.1(b)
PackingGroupIII
HS Code29051620
HS Code29309070
Hazardous Substances Data80-08-0(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg


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