Meglumine CAS#6284-40-8

Meglumine CAS#6284-40-8

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Enhances Drug Solubility: Meglumine is widely used as a counter ion to significantly improve the solubility of poorly soluble drugs.

Improves Bioavailability: By increasing drug solubility, meglumine helps enhance the bioavailability and therapeutic effectiveness of active pharmaceutical ingredients.

Well-Established Pharmaceutical Counter Ion: It is a commonly used and well-recognized counter ion in pharmaceutical formulations, offering reliable and proven performance.

Favorable Chemical Properties: As an amino sugar derived from sorbitol with a pKa of about 9.6, meglumine provides suitable ionization characteristics for forming stable drug salts.
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Product Description

Melting point129-131.5 °C (lit.)
Alpha-16.5 º (c=10, H2O, on dry sub)
Boiling point331.88°C (rough estimate)
Density1.2669 (rough estimate)
Refractive index-16.5 ° (C=2, H2O)
RTECSLZ4295770
Storage temp2-8°C
SolubilityH2O: 0.1 g/mL, clear, colorless
FormCrystalline Powder
PkapKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate)
ColorWhite to almost white
PH11 (10g/l, H2O, 20℃)
Optical activity[α]20/D 16.5±0.5°, c = 2% in H2O
Water Solubility100 g/100 mL (25 ºC)
SensitiveAir Sensitive & Hygroscopic
Merck146,078
BRN385906
InChIKeyMBBZMMPHUWSWHV-VZFHVOOUSA-N
LogP-3.370 (est)
NIST Chemistry ReferenceN-methylglucamine(6284-40-8)
EPA Substance Registry SystemMeglumine (6284-40-8)

Safety Information

Risk Statements36/37/38
Safety Statements24/25
WGK Germany3
F2003/10/23
Autoignition Temperature~662 °F
TSCAYes
HS Code29221980
ToxicityLD50 orally in Rabbit: > 5000 mg/kg


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