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Product Description
D-α-Tocopherol succinate CAS# 4345-03-3
Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2? Tocopherol succinate induces apoptosis in human gastric cancer cells3? and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

D-α-Tocopherol succinate Chemical Properties |
Melting point | ~76 °C(lit.) |
Boiling point | 625.8±55.0 °C(Predicted) |
density | 1.002±0.06 g/cm3(Predicted) |
vapor pressure | 0Pa at 20℃ |
storage temp. | -20°C |
solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol. |
form | Solid |
pka | 4.35±0.17(Predicted) |
color | White or off-white |
Odor | Little or no odor |
biological source | synthetic |
λmax | 286nm(EtOH)(lit.) |
Merck | 14,9495 |
BRN | 4038233 |
Specific Activity | 1210IU/g |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
LogP | 12 at 25℃ |
CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
Safety Information |
WGK Germany | 1 |
RTECS | EJ9984000 |
F | 8-10-23 |
HS Code | 2936280000 |
Toxicity | LD50 oral in rat: > 7gm/kg |
Product Usage
A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
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